Technology

BNA™ Basics

elminda’s BNA™ technology is based on non-invasive recordings of multi-channel EEG event-related potentials (ERPs) and a comprehensive multi-dimensional analysis of such recordings by advanced algorithms, aimed at understanding and visualizing the network complexity (or Brain Networks Activation patterns) of brain function.  Assessing the similarity to normal function can have clinical significance for understanding dysfunction, disease progression and response to therapeutic interventions in a large variety of neurologic, psychiatric and behavioral conditions.  BNA™ takes cognitive-electrophysiology (ERPs), a direct measure of neural activity associated with cognitive function, to a new frontier, unparalleled by EEG, QEEG or ERP alone or by any other anatomic and functional brain imaging and evaluation tools.  While it is not a diagnostic test by itself, its use combined with data supplied from methods available to the physician can offer additional clarity with respect to brain processes and determination of a medical condition.

The BNA™ algorithms use innovative sets of signal processing and pattern recognition techniques to seek and map activated neural pathways in task-related data points with respect to time, location, amplitude and frequency. By projecting the individual data points into clusters, BNA™ reveals three-dimensional images of Brain Network Analytics patterns (or BNAs in short) which represent high resolution functional neural pathways. These BNA™ network patterns and scores can aid clinicians with profiling of brain functionality in comparison to the RBNM (Reference Brain Network Model) to assess similarity to the normal average brain function.  Measuring changes in functionality and/or dysfunctionality can potentially assist follow-up of changes in disease progression and/or response to therapeutic interventions.

The following example schematically illustrates a BNA™ pattern associated with a specific cognitive function (functional pattern, similar to the healthy reference RBNM), a dysfunctional BNA™ pattern of the same cognitive function (dis-similar to the healthy reference RBNM), and the change of the BNA™ pattern induced by a therapeutic intervention (again, more similar to the healthy reference RBNM):

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